The first stars mark the transition from the cosmic dark ages to the modern universe that we know today, a universe that is filled with stars, galaxies, and heavy elements essential to life. The first stars stand out because of their pristine primordial initial composition and their pre-galactic formation environment. Their unique composition dramatically alter their evolution, their structure, the way they die as supernovae, and their resulting nucleosynthesis. The special circumstances under which these stars were formed also impacts their characteristic initial mass distribution, the initial mass function. Generally, it is assumed that these stars typically were significantly more massive than present-day stars. No low-mass Population III star that could have survived to the present day has ever been found. I will give an overview of the evolution and death of these first stars and their supernova. I will discuss nucleosynthesis signatures as possible diagnostics we may use at the present day to learn about these first stars, and where to find these patterns --- with the interesting perspective of potentially identifying the oldest stars in our Milky Way, which may not be the most metal-poor. Those unable to attend the colloquium in person are invited to participate online through Zoom (Meeting ID: 942 0262 2849, passcode 792771) using the link: https://eu02web.zoom-x.de/j/94202622849?pwd=dGlPQXBiUytzY1M2UE5oUDRhbzNOZz09 During his visit to Heidelberg, Professor Heger will be available for meetings by arrangement with his hosts, Friedrich Roepke (friedrich.roepke@h-its.org) and Andreas Sander (andreas.sander@uni-heidelberg.de)